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To this end, we crossed Pdzk1ip1CreER mice to the “Switch” (R26 SW) reporter, in which Cre recombination switches the expression of Tom to that of GFP Treatment of the resulting Pdzk1ip1 CreER R26 SW animals with a single dose of tamoxifen (5 mg) yielded the labeling of HSCs that was comparable to the R26 Tom reporter (Fig S3 A).

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